Publications and Patents – Molecular Plasmonics

Patents

(2016) Dynamic switching biosensor, WO2016075229
(2016) Plasmonic biosensor based on molecular conformation , WO2016075226
(2015) Biosensor based on single-molecule fluorescence detection, WO2016096908A1
(2015) Biosensor based on a tethered particle, WO2016096901A1
(2010) Optical recording, storage and retrieval product, process, system and medium, WO2016096901 A1

Books

Super-resolution microscopy for materials science
Lorenzo Albertazzi, Peter Zijlstra
CRC Press, Taylor and Francis group (2024)

2025

Nanoplasmonics for Enhanced Fluorescence Detection of Nucleic Acids: From Fundamentals to Boosting Cancer Management
David Botequim, Rui Oliveira‐Silva, Vanda Vaz Serra, Peter Zijlstra, Duarte Miguel de França Prazeres, Pedro Miguel Ribeiro Paulo
Adv. Nanobiomed Res. 5, 2400088 (2025)

Fiber-tip Photonic Crystal for Real-time Referenced Biosensing in Serum
Mathias Dolci, Paco Dreverman, Mildred S Cano-Velázquez, Arthur L Hendriks, Emiel Veth, PJ van Veldhoven, Andrea Fiore, Peter Zijlstra
Biosens. Bioelectr. X 22, 100573 (2025)

Single-Molecule Multivalent Interactions Revealed by Plasmon-Enhanced Fluorescence
Kasper R Okholm, Sjoerd W Nooteboom, Johan Nygaard Vinther, Vincenzo Lamberti, Swayandipta Dey, Ebbe Sloth Andersen, Peter Zijlstra*, Duncan S Sutherland*
ACS Nano 18, 35429-35442 (2025)

2024

Long‐term and Continuous Plasmonic Oligonucleotide Monitoring Enabled by Regeneration Approach
Abtin Saateh, Saeid Ansaryan, Jiarui Gao, Livio Oliveira de Miranda, Peter Zijlstra, Hatice Altug
Angew. Chem. Int. Ed. 63, e202410076 (2024)

Exact particle-enhanced point-spread function unlocks 3D super-resolution localization microscopy on nanoparticles
Teun Huijben, Sarojini Mahajan, Peter Zijlstra*, Rodolphe Marie*, Kim Mortensen*
ACS Nano 18, 29832-29845 (2024)

Visualizing the Heterogeneity in Homogeneous Supramolecular Polymers
Emmanouil Archontakis, Shikha Dhiman, Miao Zhang, Marle E.J. Vleugels, E.W. Meijer, Anja R.A. Palmans, Peter Zijlstra, Lorenzo Albertazzi
J. Amer. Chem. Soc. 146, 19974-19985 (2024)

Rate-Engineered Plasmon-Enhanced Fluorescence for Real-Time Microsecond Dynamics of Single Biomolecules
Sjoerd W. Nooteboom, Kasper R. Okholm, Vincenzo Lamberti, Bas Oomen, Duncan S. Sutherland, Peter Zijlstra
Nano Lett. 24, 11641–11647 (2024)

Ordered aqueous structures from liquid-liquid phase separation by supramolecular polymerizations
Hailin Fu, Jingyi Huang, Joost Van der Tol, Lu Su, Swayandipta Dey, Peter Zijlstra, Ghislaine Vantomme, Patricia Dankers, Bert Meijer
Nature 626, 1011-1018 (2024)

Detecting single nanoparticles using fiber-tip nanophotonics
Arthur L. Hendriks, Daan Rabelink, Mathias Dolci, Paco Dreverman, Mildred S. Cano-Velázquez, Luca Picelli, René P. J. van Veldhoven, Peter Zijlstra, Ewold Verhagen, and Andrea Fiore
Optica 11, 512-518 (2024)

Biomolecular interactions on densely coated nanoparticles: a single-molecule perspective
Swayandipta Dey, Rodrigo Rivas-Barbosa, Francesco Sciortino, Emanuela Zaccarelli, Peter Zijlstra
Nanoscale 16, 4872-4879 (2024)

Continuous Monitoring Biosensing Mediated by Single-Molecule Plasmon-Enhanced Fluorescence in Complex Matrices
Vincenzo Lamberti, Mathias Dolci, Peter Zijlstra
ACS Nano 18, 5805–5813 (2024)

T. van Loon, M. Liang, T. Delplace, B. Maes, S. Murai, P. Zijlstra, and J. Gómez Rivas
Refractive index sensing using quasi-bound states in the continuum in silicon metasurfaces
Opt. Express 32, 14289-14299 (2024)

2023

Real-time Optical Tracking of Protein Corona Formation on Single Nanoparticles in Serum
Mathias Dolci, Yuyang Wang, Sjoerd W Nooteboom, Paul ED Soto Rodriguez, Samuel Sanchez, Lorenzo Albertazzi, Peter Zijlstra
ACS Nano 17, 20167–20178 (2023)

A single-particle plasmon sensor to monitor proteolitic activity in real-time
Rui Oliveira-Silva, Yuyang Wang, Sjoerd Nooteboom, Duarte M. F. Prazeres, Pedro M. R. Paulo, Peter Zijlstra
ACS Appl. Opt. Mater. 1, 1661-1669 (2023)

Precision and accuracy of receptor quantification on synthetic and biological surfaces using DNA-PAINT
Roger Riera Brillas, Emmanouil Archontakis, Glenn A.O. Cremers, Tom F.A. de Greef, Peter Zijlstra*, Lorenzo Albertazzi*
ACS Sens. 8, 80–93 (2023)

Single-Molecule Optical Biosensing: Recent Advances and Future Challenges
Swayandipta Dey, Mathias Dolci, Peter Zijlstra
ACS Phys. Chem. Au 3, 143-156 (2023)

Integrated signal amplification on a fiber optic SPR sensor using duplexed aptamers
Annelies Dillen, Claudia Scarpellini, Woud Daenen, Seppe Driesen, Peter Zijlstra, Jeroen Lammertyn
ACS Sens. 8, 811-821 (2023)

2022

Sjoerd W. Nooteboom, Yuyang Wang, Swayandipta Dey, Peter Zijlstra
Real-Time Interfacial Nanothermometry using DNA-PAINT Microscopy
Small 18, 2201602 (2022)

Spectrally PAINTing a Single Chain Polymeric Nanoparticle at Super-Resolution
Emmanouil Archontakis, Linlin Deng, Peter Zijlstra*, Anja R. A. Palmans*, Lorenzo Albertazzi*
J. Am. Chem. Soc. 144, 23698–23707 (2022)

Yuyang Wang, Paul E.D. Soto Rodriguez, Laura Woythe, Samuel Sánchez, Josep Samitier, Peter Zijlstra*, Lorenzo Albertazzi*
Multicolor Super-Resolution Microscopy of Protein Corona on Single Nanoparticles
ACS Appl. Mater. Interfaces 14, 37345–37355 (2022)

2021

Frank Bloksma, Peter Zijlstra
Imaging and Localization of Single Emitters near Plasmonic Particles of Different Size, Shape and Material
J. Phys. Chem. C 125, 22084-22092 (2021)

Michael A Beuwer, Peter Zijlstra
Correlative Microscopy of single self-assembled nanorod dimers for refractomteric sensing
J. Chem. Phys. 155, 044701 (2021)

Yuyang Wang, Heiner Friedrich, Ilja K Voets, Peter Zijlstra, Lorenzo Albertazzi
Correlative imaging for polymer science
J. Polym. Sci. 59, 1232-1240 (2021)

2020

Rachel E. Armstrong, Matěj Horáček, Peter Zijlstra
Plasmonic Assemblies for Real-Time Single Molecule Biosensing
Small 16, 2003934 (2020)

Junhong Yan, Laura van Smeden, Maarten Merkx, Peter Zijlstra, Menno W.J. Prins
Continuous small-molecule monitoring with a digital single particle switch
ACS Sens. 5, 1168–1176 (2020)

Wang, M. Horáček, P. Zijlstra
Strong Plasmon Enhancement of the Saturation Photon Count Rate of Single Molecules
J. Phys. Chem. Lett. 11, 1962-1969 (2020)

M. Horáček, D. J. Engels, P. Zijlstra
Dynamic single-molecule counting for the quantification and optimization of nanoparticle functionalization protocols
Nanoscale 12, 4128-4136 (2020)

2019

Y. Wang, K. van Asdonk, and P. Zijlstra
A Robust and General Approach to Quantitatively Conjugate Enzymes to Plasmonic Nanoparticles
Langmuir 35, 13356-13363 (2019)

R.E. Armstrong, W. van Liempt, and P. Zijlstra
Effect of Film Thickness on the Far- and Near-Field Optical Response of Nanoparticle-on-Film Systems
J. Phys. Chem. C 132, 25801-25808 (2019)

2018

Emiel W.A. Visser, Matěj Horáček, and Peter Zijlstra
Plasmon Rulers as a Probe for Real-Time Microsecond Conformational Dynamics of Single Molecules
Nano Lett, 18, 7927–7934 (2018)

Y. Wang, and P. Zijlstra
Plasmon-Enhanced Single-Molecule Enzymology
ACS Photonics 5, 3073-3081 (2018)

P. M. R. Paulo, D. Botequim, A. Jóskowiak, S. Martins, D. M. F. Prazeres, P. Zijlstra, and S. M. B. Costa
Enhanced Fluorescence of a Dye on DNA-Assembled Gold Nanodimers Discriminated by Lifetime Correlation Spectroscopy
J. Phys. Chem. C 122, 10971–10980 (2018)

A.T. Taylor, R. Verhoef, M.A. Beuwer, Y. Wang, and P. Zijlstra
All-optical imaging of gold nanoparticle geometry using super-resolution microscopy
J. Phys. Chem. C 122, 2336–2342(2018)

2017

M. Horacek, R. E. Armstrong, and P. Zijlstra
Heterogeneous kinetics in the functionalization of single plasmonic nanoparticles
Langmuir 34, 131–138 (2018)

A.T. Taylor, and P. Zijlstra
Single-molecule plasmon sensors: current status and future prospects (review)
ACS Sensors 2, 1103-1122 (2017)

P.M.R. Paulo, P. Zijlstra, M. Orrit, E. Garcia-Fernandez, T. Pace, A. Viana, S. Costa
Tip-Specific Functionalization of Gold Nanorods for Plasmonic Biosensing: Effect of Linker Chain Length
Langmuir 33, 6503-6510 (2017)

2016

M.A. Beuwer, M.F. Knopper, L. Albertazzi, D. van der Zwaag, W.G. Ellenbroek,
E.W. Meijer, M.W.J. Prins and P. Zijlstra
Mechanical Properties of Single Supramolecular Polymers from Correlative AFM and Fluorescence Microscopy
Polym. Chem. 7, 7260-7268 (2016)

S.M.E. Peters, M.A. Verheijen, M.W.J. Prins, P. Zijlstra
Strong reduction of spectral heterogeneity in gold bipyramids for single-particle and single-molecule plasmon sensing
Nanotechnology 27, 024001 (2016)

2015

M.A. Beuwer, Menno W.J. Prins, P. Zijlstra
Stochastic protein interactions monitored by hundreds of single-molecule plasmonic biosensors
Nano Lett. 15, 3507-3511 (2015)

2014

S. Khatua, P.M.R. Paulo, H. Yuan, A. Gupta, P. Zijlstra, and M. Orrit
Resonant plasmonic enhancement of single-molecule fluorescence by individual gold nanorods
ACS Nano 8, 4440-4449 (2014)

K. Yu, J.E. Sader, P. Zijlstra* (corresponding author), M. Hong, Q.-H. Xu, M. Orrit
Probing silver deposition on single gold nanorods by their acoustic vibrations
Nano Lett. 14, 915-922 (2014)

H. Yuan, S. Khatua, P. Zijlstra, and M. Orrit
Individual gold nanorods report on dynamical heterogeneity in supercooled glycerol
Faraday Discuss 167, 515-528 (2014)

2013

P.G. van Rhee, P. Zijlstra, T. Verhagen, J. Aarts, M.I. Katsnelson, J.C. Maan, M. Orrit, and P.C.M. Christianen
Giant magnetic susceptibility of gold nanorods detected by magnetic alignment
Phys. Rev. Lett. 111, 127202 (2013)

K. Yu, P. Zijlstra*, J.E. Sader, Q.-H. Xu, and M. Orrit
Damping of acoustic vibrations of single gold nanorods in different environments
Nano Lett. 13, 2710-2716 (2013)

G. Hartland, H. Okamoto, M. Orrit, and P. Zijlstra
Optical studies of single metal nanoparticles (editorial)
Phys. Chem. Chem. Phys. 15, 4090-4092 (2013)

H. Yuan, S. Khatua, P. Zijlstra, M. Yorulmaz, and M. Orrit
Thousand-fold enhancement of single-molecule fluorescence near a single gold nanorod
Angew. Chem. Int. Ed. 52, 1217-1221 (2013)

2012

M. Yorulmaz, S. Khatua, P. Zijlstra, A. Gaiduk, and M. Orrit
Luminescence quantum yield of single gold nanorods
Nano Lett. 12, 4385-4391 (2012)

P. Zijlstra, P.M.R. Paulo, K. Yu, and M. Orrit
Chemical interface damping in single gold nanorods and its near elimination by tip-specific functionalization
Angew. Chem. Int. Ed. 51, 8352-8355 (2012)

P. Zijlstra, P.M.R. Paulo, and M. Orrit
Optical detection of single non-absorbing molecules using the surface plasmon resonance of a single gold nanorod
Nature Nanotech. 7, 379-382 (2012)
Reprinted in Nature Outlook on “Gold” (Nature 495, S1, 2013)

P. Zijlstra, M. van Stee, N. Verhart, Z. Gu, and M. Orrit
Rotational diffusion and alignment of short gold nanorods in an external electric field
Phys. Chem. Chem. Phys. 14, 4584-4588 (2012)

P.V. Ruijgrok, P. Zijlstra, A.L. Tchebotareva, and M. Orrit
Damping of acoustic vibrations of single gold nanoparticles optically trapped in water
Nano Lett. 12, 1063-1069 (2012)

2011

P. Zijlstra, and M. Orrit
Single metal nanoparticles: optical detection, spectroscopy and applications
Rep. Progr. Phys. 74, 106401 (2011)

C. Bullen, P. Zijlstra, E. Bakker, M. Gu, and C. Raston
Chemical kinetics of gold nanorod growth in aqueous CTAB solutions
Cryst. Growth Des. 11, 3375-3380 (2011)

P.V. Ruijgrok, N. Verhart, P. Zijlstra, A.L. Tchebotareva, and M. Orrit
Brownian fluctuations and heating of an optically aligned gold nanorod
Phys. Rev. Lett. 107, 037401 (2011)

2004-2010

A.L. Tchebotareva, P. Ruijgrok, P. Zijlstra, and M. Orrit
Probing the acoustic vibrations of single metal nanoparticles by ultrashort laser pulses
Laser. Photon. Rev. 4, 581-597 (2010)

P. Zijlstra, J.W.M. Chon, and M. Gu
White light scattering spectroscopy and electron microscopy of laser induced melting in single gold nanorods
Phys. Chem. Chem. Phys. 11, 5915 – 5921 (2009)

P. Zijlstra. J.W.M. Chon, and M. Gu
Five-dimensional optical recording mediated by surface plasmons in gold nanorods
Nature 459, 410-413 (2009)
Featured on the cover of Nature, 21 May 2009

P. Zijlstra, A.L. Tchebotareva, J.W.M. Chon, M. Gu, and M. Orrit
Acoustic oscillations and elastic moduli of single gold nanorods
Nano Lett. 8, 3493-3497 (2008)

K. Choi, P. Zijlstra, J.W.M. Chon, and M. Gu
Fabrication of Low-Threshold 3D Void Structures inside a Polymer Matrix Doped with Gold Nanorods
Adv. Funct. Mater. 18, 2237-2245 (2008) Feature on inside cover

P. Zijlstra, J.W.M. Chon, and M. Gu
Effect of heat accumulation on the dynamic range of a gold nanorod doped polymer nanocomposite for optical laser writing and patterning
Opt. Expr. 15, 12151-12160 (2007)

P. Zijlstra, K.L. van der Molen, and A.P. Mosk
Spatial refractive index sensor using whispering gallery modes in an optically trapped microsphere
Appl. Phys. Lett. 90, 161101 (2007)

J.W.M. Chon, C. Bullen, P. Zijlstra, and M. Gu,
Spectral encoding on gold nanorods doped in a silica sol-gel matrix and its application to high-density optical data storage
Adv. Funct. Mater. 17, 875-880 (2007)

P. Zijlstra, C. Bullen, J.W.M. Chon, and M. Gu
High-temperature seedless synthesis of gold nanorods
J. Phys. Chem. B 110, 19315-19318 (2006)

K.L. van der Molen, P. Zijlstra, A. Lagendijk, and A.P. Mosk
Laser threshold of Mie resonances
Opt. Lett. 31, 1432-1434 (2006)

J.W. M. Chon, P. Zijlstra, M. Gu, J. Van Embden, and P. Mulvaney
Two-photon-induced photoenhancement of densely packed CdSe/ZnSe/ZnS nanocrystal solids and its application to multilayer optical data storage
Appl. Phys. Lett. 85, 5514-5516 (2004)